MS-DOS 6.0 released in March 1993 was a catch- p with Digital Research DR-DOS 6. It added a disk-compression utility called DoubleSpace, a basic anti-virus program and a disk defragmenter. It also finally included a MOVE command, an improved backup program - MSBACKUP and multiple boot configurations. Memory management was also improved by the addition of MEMMAKER. A number of older utilities, such as JOIN and RECOVER were removed. The DOS Shell was released separately as Microsoft felt that there were too many disks.

Shortly after the release there were complaints of data loss when using the DriveSpace utility. Version 6.2 addressed the issue.